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VON WILLEBRAND FACTOR CLEAVING PROTEASE
Descriptors Found:
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DeCS
Descriptor
English
:
ADAMTS13 Protein
Descriptor
Spanish
:
proteína ADAMTS13
Descriptor
Portuguese
:
Proteína ADAMTS13
Synonyms
English
:
A Disintegrin and Metalloproteinase with Thrombospondin Motifs 13 Protein
ADAMTS 13 Protein
ADAMTS-13 Protein
ADAMTS13 Protease
vWF Cleaving Protease
vWF-Cleaving Protease
von Willebrand Factor Cleaving Protease
von Willebrand Factor-Cleaving Protease
Tree Number:
D08.811.277.656.675.374.102.500.813
D09.400.430.500.500.813
D12.776.395.033.500.813
D12.776.860.300.085.813
Definition
English
:
An ADAMTS protease that contains eight
thrombospondin
(TS) motifs. It cleaves
VON WILLEBRAND FACTOR
to
control
vWF-mediated
THROMBOSIS
.
Mutations
in the ADAMTS13 gene have been identified in familial cases of
PURPURA
, THROMBOTIC THROMBOCYTOPENIC and defects in ADAMTS13 activity are associated with
MYOCARDIAL INFARCTION
;
BRAIN ISCHEMIA
;
PRE-ECLAMPSIA
; and
MALARIA.
History Note
English
:
2017
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
56487
Unique Identifier:
D000071120
Occurrence in VHL
:
Similar:
DeCS